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Withdrawal signs (such as anxiety, sweating, insomnia, nausea, diarrhea, discomfort, piloerection [bristling of hairs] have actually been reported when tramadol has actually been quickly stopped complying with application for extensive amount of times. The dose of tramadol need to always be reduced gradually on discontinuation. Tramadol may be made use of for the therapy of moderate-to-severe pain such as that brought on by cancer cells, osteoarthritis, and various other musculoskeletal diseases.
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